We also sought to test whether Haao−/−, and Kmo−/− mice would also have resistance to nephrotoxic-induced AKI but here we administered a single intraperitoneal dose of cisplatin to separate groups of knockouts and WT mice (25 mg/kg) and sacrificed 72 hours later to assess kidney injury (Fig. 5A). QA levels were significantly increased in cisplatin-administered WT mice and significantly reduced in both kidney tissue and plasma of cisplatin-administered Haao−/− and Kmo−/− mice (Fig. 5B-C). Suppression of QA synthesis was associated with marked renal protection. The gene discussed is HAAO; the disease is acute kidney injury.