For example, CRISPRa-based CRT has been shown to rescue disease-relevant phenotypes in models of haploinsufficiency for genes including SCN1A (epilepsy), KCN1A (epilepsy), TCF4 (Pitt-Hopkins syndrome, PTHS), SCN2A (ASD) and CHD8 (ASD)24-28. Here, CHD8 is linked to Pitt-Hopkins syndrome.