CTNND2 and Cri-du-chat syndrome: Targeting of the enhancer located 112 kb upstream yielded upregulation of CTNND2 specifically in the two Cri-du-chat syndrome iPSC lines, but not HEK293T cells (1.8-fold, q = 9e-5; 2.1-fold, q = 2e-7; Fig. 5f-h).