RMRP and ganglioneuroma: As expected7,12,13, CG methylation over CG hypo DMRs was dramatically decreased in the wild-type VN nuclei, whereas CHH methylation over CHH hyper DMRs decreased in MN, remained low in GN and SN, and greatly increased in the VN (Fig. 3d–e, Extended Data Fig. 6c).13 CHG methylation levels at CG hypo DMRs were also mildly decreased, despite the increase observed at pericentromeres (Extended Data Fig. 6b–c).