CFH and age-related macular degeneration: Based on the preferential localization of CFH on rods, which are primarily responsible for dark adaptation, coupled with the CFH-dependent IFT52/OSM-6 and CNG distribution defects shown here, it may be reasonable to speculate that mis-localization of visual cycle components, including CNG, that affect intracellular calcium and cGMP levels, may contribute to delayed RMDA and other early manifestations of AMD.