A significant decrease in the relative quantity of CNGA1 and CNGB1 in inner segments when compared to outer segments was detected in AMD high-risk CFH Y402H variants (Fig. 4B,C), suggesting that CFH not only maintains inversin compartment boundaries (15), but also regulates the distribution of CNG channels in photoreceptor outer segments and that function is compromised in individuals at high-risk for AMD. The gene discussed is CNGA1; the disease is age-related macular degeneration.