Mechanistically, we show that 3222401L13Rik interacts with PU.1, an AD-associated myeloid transcription factor {Huang, 2017} {Pimenova, 2020} {Ralvenius, 2024}, and that 3222401L13Rik-dependent genes substantially overlap PU.1 targets. Here, SPI1 is linked to Alzheimer disease.