In 217 clinical and neuropathologically confirmed AD versus 290 no-dementia controls donors, we identify 613 differentially expressed genes (390 up, 223 down; |log2 fold change| ≥ 0.5; BH P < 0.05), with NPNT and ADAMTS2 among the top upregulated signals. This evidence concerns the gene ADAMTS2 and dementia.