CFH-1 and TEP-1 localization and phenotypes, combined with prior demonstrations of CFH localization on vertebrate photoreceptor outer segments (14,22,23,30,31), and cilia compartment defects in AMD high-risk CFH variant photoreceptors (14), raised questions regarding CFH and C3 localization in human photoreceptors. The gene discussed is C3; the disease is age-related macular degeneration.