MECP2 and Anxiety: We evaluated the effects of the compound (R)-α-methylhistamine (RAMH, 45 mg/kg, ip), an agonist of the H3 receptor (Arrang, Devaux et al. 1988, Arrang, Garbarg et al. 1988, Rapanelli, Frick et al. 2016) on several behavioral phenotypes in symptomatic 20-week-old Mecp2+/+ and Mecp2Null/+ female RTT model mice: locomotion in an open field, anxiety as assessed by elevated zero maze, repetitive behavior using a hindlimb clasping measurement, and learning and memory in a Pavlovian task, conditioned fear.