In summary, this study performed scRNA‐seq on the kidneys of HUA mice and demonstrated that EA at BL23 alleviated HUA‐induced nephropathy by exerting anti‐inflammatory effects inhibiting the secretion of TNF‐α, IL‐1β, and IL‐6, through the downregulation of both the NLRP3 inflammasome and the IL‐6/JAK/STAT3 signaling pathway. This evidence concerns the gene NLRP3 and kidney disorder.