KNSTRN and neoplasm: Functional studies in which wild-type or p.Ser24Phe mutant KNSTRN complementary DNA (cDNA) were expressed in keratinocytes, as well as analyses on wild-type versus mutant SCC samples, supported that the identified KNSTRN mutation compromises accurate chromosome segregation during cell replication, contributing to aneuploidy and enhanced oncogene-driven tumor growth in vivo.