PAX2 and kidney failure: ,27, 28, 29,31, 32, 33, 34, 35, 36, 37, 38 Of these, 56 carriers of a PAX2 LOF variant (54%) had kidney failure before the age of 18 years (Supplementary Table S2) with a median age of 9.5 years (range: 2 weeks–17.5 years).