,2 Urine tubular biomarkers such as dickkopf-3, interleukin-18 (IL-18), kidney injury molecule-1, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin, and human cartilage glycoprotein-40 (YKL-40) have been investigated in the context of acute kidney injury, kidney function decline, kidney drug monitoring, and tubulointerstitial fibrosis. The gene discussed is IL18; the disease is acute kidney injury.