An alternative explanation is that vincristine directly affects podocytes, supported by our data showing that direct vincristine addition to FSGS presentation serum protected podocytes from the serum-induced changes in tubulin and F-actin and attenuated albumin leakage seen in the GOAC in 2 of the patients with FSGS examined. The gene discussed is ALB; the disease is focal segmental glomerulosclerosis.