Cystic degeneration is one of the predictors of gastrointestinal stromal tumors with high malignant potential (14).GIST can usually express CD34, CD117, DOG-1, in immunohistochemical results, and some cases can also express S-100, SMA, while β-catenin is usually not expressed (15).It has been reported in the literature that GIST and AF may be susceptible and can be combined (16). This evidence concerns the gene ANO1 and atrial fibrillation.