LINC00539 and myeloid leukemia: Third, integrative analysis identified 570 genes upregulated at both the eccDNA and mRNA levels, including myeloid leukemia drivers (FLT3, RUNX1, CD33) and oncogenes (MAP2K2/3, LINC00539), mirroring the “eccDNA–oncogene amplification” axis observed in solid tumors.