RNF8 and acute myeloid leukemia: Finally, prognostic analysis using TCGA datasets (https.//gepia2.cancer-pku.cn) showed that high expression (median cutoff) of these tumor-related genes including FLT3, D2HGDH, MAPK2, RNF8, SCAMP5, SNX8, ARHGAP22, and ESPL1 correlated with poor outcomes in AML patients (Figures 2F, G).