Finally, prognostic analysis using TCGA datasets (https.//gepia2.cancer-pku.cn) showed that high expression (median cutoff) of these tumor-related genes including FLT3, D2HGDH, MAPK2, RNF8, SCAMP5, SNX8, ARHGAP22, and ESPL1 correlated with poor outcomes in AML patients (Figures 2F, G). This evidence concerns the gene ARHGAP22 and acute myeloid leukemia.