In addition, Gene Ontology (GO) enrichment analysis with upregulated eccDNA-carrying genes in AML revealed enrichment in specific biological processes (BPs), including “cell growth,” “Ras protein signal transduction,” “histone modification,” and “ERBB signaling pathway”; cellular components (CCs), including “histone deacetylase complex,” “SWI/SNF superfamily-type complex,” and “protein phosphatase type 2A complex”; and molecular function (MFs), including “GTPase regulator activity,” “protein serine kinase activity,” and “14-3–3 protein binding” (Supplementary Figure S2). Here, EGFR is linked to acute myeloid leukemia.