Given the critical role of the Hippo–YAP/TAZ signaling pathway in regulating cell proliferation, migration, and differentiation (Ma et al., 2019), its sustained activation contributes to pulmonary vascular remodeling in PAH (Kudryashova et al., 2016; Wang et al., 2019; Kudryashova et al., 2022). The gene discussed is YAP1; the disease is pulmonary arterial hypertension.