CHD4 depletion causes accumulation of p62 and an increase in the LC3 II/I ratio, suggesting a block in late-stage autophagy in HER2-positive breast cancer cells, further contributing to growth arrest in cancer cells upon CHD4 loss (D’Alesio et al., 2017; D'Alesio et al., 2019). The gene discussed is ERBB2; the disease is breast cancer.