For example, the manipulation of the Armadillo repeats (ARM) domain of the ARID1B subunit may disrupt ARID1B interaction with other subunits in the SWI/SNF complex and induce synthetic lethality in ARID1A-deficient cancers (Takada et al., 2012; Yu et al., 2013). This evidence concerns the gene ARID1A and cancer.