However, various knockout and knockdown studies on BRG1 and BRM further confirmed its role in maintaining cellular proliferation, in which the absence or reduced expression of BRG1 or BRM significantly decreases the proliferation rate of breast cancer cells in both in vivo and in vitro models (Bai et al., 2013; Wu et al., 2015). The gene discussed is SMARCA4; the disease is breast carcinoma.