Genetic alterations of ISWI members are commonly reported in many types of cancers, and they also correlate with poor prognosis of breast cancer patients (Pérez-Pena et al., 2019; Li et al., 2021), as ISWI ATPases interact with numerous DNA-binding factors and cofactors involved in malignant cell transformation and progression (Mayes et al., 2017; Koedoot et al., 2019). The gene discussed is SMARCA5; the disease is breast carcinoma.