SOX2 and neoplasm: However, in other cancers, such as gastric and liver, RBBP4 is recruited as a part of the NURF complex to promote transcription of certain factors [e.g., SRY-Box Transcription Factor 2 (SOX2) and Octamer-Binding Transcription Factor 4 (OCT4)] that drive tumor progression (Zhu et al., 2015; Ding et al., 2019; Cai et al., 2023).