FAS and neoplasm: Additionally, BPTF-deficient tumor cells may exhibit increased perforin, granzyme, and IFN-g due to enhanced T-cell cytotoxicity, which may induce Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) and Fas Cell Surface Death Receptor/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Fas/TRAIL) pathways (Mayes et al., 2016; Mayes et al., 2017).