The most common example of these interactions is provided by the combination of mutually exclusive gene paralogues, such as in cancers with ARID1A mutation that require ARID1B for survival or tumors with BRG1 deficiency, which are sensitive to SMARCA2 depletion (Kaelin, 2009; Helming et al., 2014; Hoffman et al., 2014). Here, SMARCA4 is linked to cancer.