Development of E3 ligases for CHD7 degradation may be beneficial for breast cancer treatment (Stark et al., 2006; Wagner et al., 2011; Beltrao et al., 2012; Povlsen et al., 2012; Akimov et al., 2018; Ordureau et al., 2020; Pedersen et al., 2021). The gene discussed is CHD7; the disease is breast carcinoma.