OCRL and oculocerebrorenal syndrome: Cell phenotypes are being studied in multiple laboratory models, including human embryonic kidney 293 T epithelial and proximal tubule HK2 cells (Ramadesikan et al., 2021; Lee J. J. et al., 2023), proximal tubular cells from transgenic mice (Berquez et al., 2020), neuronal cells induced from Lowe syndrome patient-derived pluripotent stem cells (Akhtar et al., 2022; Barnes et al., 2018), patient-derived platelets (Egot et al., 2021), Ocrl1-inhibited human thrombocytes (Bura et al., 2023) and transgenic zebrafish (Lowe, 2025).