The same OCRL gene variant is known to cause clinical features of Lowe syndrome in one patient and of Dent 2 in another and to manifest different features or different severity of features between families and even within affected boys of the same family (Zaniew et al., 2018; Hichri et al., 2011; Du et al., 2024; Ando et al., 2024; Akhtar et al., 2022). The gene discussed is OCRL; the disease is oculocerebrorenal syndrome.