In the late stage of GU cancer, adaptive changes become an important factor in cancer immune tolerance, mainly involving dynamic modifications of the tumor, i.e., the tumor resisting immune system attacks during treatment, such as the emergence of an immunosuppressive tumor microenvironment formed by the synergistic action of IL-8 and VEGF (Kim, 2020; Martin et al., 2009). This evidence concerns the gene VEGFA and neoplasm.