PRNP and Alzheimer disease: A key hallmark of major neurodegenerative disorders—including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), synucleinopathies and prion diseases—is the intracellular accumulation of aggregated proteins such as MAPT, TDP43, FUS, PRNP and SNCA (Wilson et al., 2023).