Based on histomorphology, immunohistochemical profile (S-100(+), p63(partial +), CK(pan)(−), CK8/18(−), DOG1(partial +), Ki67(+, 5%), p53(scattered +), SATB2(partial +), MDM2(small foci +), CDK4(small foci +), H3.3G34W(−), H3K36M(+), Ki67(5%+), MDM2(osteoclast+), P53(10%+)), and clinical presentation, chondroblastoma was diagnosed (Figure 3). Here, TP53 is linked to chondroblastoma.