The expression levels of Variance Adjusted Response Selection (VARS) and CTNND1 were significantly downregulated in AHO samples compared to healthy samples (P < 0.05) (Figures 4A–C), while the expression levels of MPO and PRTN3 were significantly upregulated in AHO samples (P < 0.05) (Figures 4D,E). The gene discussed is MPO; the disease is pseudohypoparathyroidism type 1A.