Following ulcer onset, decreased levels of NO, iNOS, PGE2, and MTL, alongside increased levels of TNF-α, IL-6, and MDA, directly induce a reduction in the abundance of bacteria, including Rothia, Streptococcus, Corynebacterium, Globicatella, Romboutsia, and Lactobacillus, with this effect being more pronounced in the oral cavity. This evidence concerns the gene IL6 and ulcer disease.