In sepsis-induced myocardial injury models, H2S downregulates TLR4 and NLRP3 protein expression, inhibits MyD88-NF-κB signaling activation to reduce cytokine secretion, and blocks NLRP3 inflammasome assembly and IL-1β processing (Xia et al., 2023). The gene discussed is TLR4; the disease is Sepsis.