ACAA1 and nasopharyngeal carcinoma: Our analysis showed that ACAA1 expression was statistically lower in TME subtype I compared to subtype II and III (TME subtype I vs. subtype II, p < 0.001; TME subtype I vs. subtype III, p < 0.001), suggesting that reduced ACAA1 expression may be associated with poor clinical outcomes in NPC (Figure 6D).