HLA-C and Alzheimer disease: Many KIRs exist, some of which induce activation such as KIR2DS1 and some of which induce inhibition such as KIR2DL1, both of which bind to a subset of HLA-C proteins.42 Whilst not the focus of this review, given the breadth of the topic, it is worth highlighting that very little is known about the possible contribution of KIRs on NK cells and T cells and their interaction to HLA-I molecules expressed within the AD brain.