MAPT and Alzheimer disease: The first line of evidence to support this is the suggestion that protective alleles of the DRB1*04 family present acetylated tau-derived epitopes based on the observation that they bind to acetylated tau PHF6 peptides in-vitro.18 In parallel, a second study observed that possessing the alleles DQB1*02:01 or DQB1*02:02 was associated with reduced tauopathy in the brain,65 although it should be noted that no association of AD with alleles belonging to the DQB1*02 family have previously been reported.