Amyloid-β possesses anti-microbial properties in-vitro57 and bacterial DNA have been shown to promote tau aggregation58 with a recent study suggesting a direct anti-viral function of tau downstream of the cGAS-STING pathway following infection with HSV1.59 These propositions are in line with the observed colocalization of HSV1 DNA within amyloid plaques60 and the colocalization of the HSV-1 protein ICP27 and hyperphosphorylated tau aggregates in the brain of AD patients.59 Here, MAPT is linked to Alzheimer disease.