HLA-DRB1 and Alzheimer disease: Detailed imputation of the HLA locus restricted to clinically diagnosed AD cases reported HLA-II risk alleles (DQA1*01:01, DQB1*05:01 and DRB1*01:01), HLA-II protective alleles (DQA1*03:01, DQB1*03:02 and DRB1*04:04) and HLA-I risk alleles (A*02:01 and B*57:01) in two distinct haplotypes; risk haplotype DRB1*01:01∼ DQA1*01:01∼DQB1*05:01 (OR 1.06–1.14) and protective haplotype DRB1*04:04∼DQA1*03:01∼DQB1*03:02 (OR 0.87).12,18 As outlined in Table 1 and Table 2, this recent GWAS of enormous proportions provides evidence in agreement with other previous reports.