MAPT and Alzheimer disease: Mesial temporal lobe and hippocampal white matter dysconnectivity is a consistent finding in Alzheimer’s Dementia (Ad), present preclinically and progressing to the structurally connected frontal and parietal regions.51 Structural network alterations in Ad also appear to be driven by the cumulative spread of tau, a process similarly observed in NPC.52,53 Our results suggest that the pathological accumulation of tau may also drive structural network changes in NPC that resemble those in Ad.