MAPT and Alzheimer disease: In the cellular neuropathology of AD, and other dementia processes, it is notable the formation neurofibrillary tangles resultant of hyperphosphorylated tau protein aggregates; its appearances can be caused by Aβ oligomerization and tau mutations (Oddo et al. 2003); tau proteins are a group of six highly soluble protein isoforms produced by MAPT gene alternative splicing; it is highly abundant in neurons with a direct role in axon microtubules stabilization.