ATP13A2 (PARK9) encodes for lysosomal P‐type ATPase, while the yeast counterpart YPK9 encodes a vacuolar transporter with a possible role in sequestering divalent heavy metals, which are assumed environmental risk factors for PD; yeast YPK9 protects cells from manganese toxicity and α‐synuclein cytotoxicity. This evidence concerns the gene ATP13A2 and Parkinson disease.