Similarly, in multicellular organisms, PGC‐1α is a transcriptional activator that regulates mitochondrial biogenesis, and its excess in Drosophila melanogaster also attenuates polyQ‐induced toxicity, indicating a conserved mechanism and a possible intervention for HD treatment by modulation of PGC‐1α levels (Ruetenik et al. 2016; Q. Zhang et al. 2019; D'Egidio et al.2025). Here, PPARGC1A is linked to Huntington disease.