ADORA2A and infection: So far, we suggested that HO-1 expression depends on A2AR activation, and since HO-1 is a heme-degrading enzyme, we further checked heme content in infected ZM 241385-treated samples, and as expected, ZM 241385 reversed the infection-induced decrease in heme content (2.9-fold increase compared to infected control, P = 0.0002) (Fig. 1I).