ChIP assay showed significantly reduced nuclear NRF2 binding to the HO-1 promoter in CA-GSK-3β-transfected infected cells (74.2% compared to WT-GSK-3β-transfected L. donovani-infected cells, P < 0.0001) at 8 h post-infection (Fig. 4H). The gene discussed is HMOX1; the disease is infection.