Recently, plitidepsin (Aplidin), an analog of didemnin B and a potent anti-cancer agent targeting eEF1A2 (KD = 80 nM) (25), was shown to be highly potent against SARS-CoV-2 by targeting eEF1A, with a 90% inhibitory concentration (IC90) of 0.88 nM (26). The gene discussed is EEF1A1; the disease is cancer.