Invasion and migration are critical stages in tumor development, influenced by p65-dependent factors such as matrix metalloproteinases, urokinase fibrinogen activators, and interleukin-8 (Gonzalez-Avila et al., 2020; Cox, 2021; Kwaan and Lindholm, 2019; Mego et al., 2015; Kim, 2020). The gene discussed is CXCL8; the disease is neoplasm.