Postprandial hyperinsulinemia has been reported to be attenuated with postprandial physical activity (Bellini, Nicolo, Bazzucchi, & Sacchetti, 2022; Bellini, Nicolo, Rocchi, et al., 2022; Engeroff et al., 2023; Gale et al., 2023) via an “insulin independent” transport mechanism whereby a contracting muscle activates the AMP‐activated protein kinase (AMPK) pathway that turns on Glucose transporter type 4 (GLUT‐4) to move glucose into the muscle (Goodyear & Kahn, 1998; Kjobsted et al., 2017; Ryder et al., 2001). The gene discussed is INS; the disease is hyperinsulinism.