Next, using human scRNA-Seq comparing T2D and non-T2D wounds, we found that TNF-α signaling and Setdb2 expression were increased in T2D wound fibroblasts compared with non-T2D fibroblasts, which correlates with the reduced myofibroblast phenotype found in T2D wounds. This evidence concerns the gene SETDB2 and type 2 diabetes mellitus.