The increases in IL-6 levels are linked with metabolic disease severity in humans (66) Akin to immune cells, white adipocyte sensing of inflammatory environment may yield changes in the intracellular metabolism and trigger production of various cytokines/adipokines and chemokines, in turn promoting systemic and tissue inflammation (e.g., accrual of diverse immune cells in WAT). The gene discussed is IL6; the disease is metabolic disease.