PKM and Insulin resistance: Notably, TEPP-46 treatment of PKM2-sufficient (WT + Pkm2fl/fl AdipoqCre–) mice improved fasting glucose (Figure 5B; first compared with second violin plot), fasting insulin (Figure 5C; first compared with second violin plot), and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index value (Figure 5D; first compared with second violin plot) while showing a trend in reduction of systemic ALT levels (Figure 5E; first compared with second violin plot) and reduction in liver triglyceride accumulation (Figure 5F; first compared with second violin plot).