ADIPOQ and obesity due to melanocortin 4 receptor deficiency: As such, to maximize the utility and reduce the number of control mice in obesity-related studies, data obtained from WT and Pkm2fl/fl AdipoqCre– (untreated and vehicle treated) mice were combined (termed Pkm2fl/fl Adipoq sufficient) and compared with data from Pkm2fl/fl AdipoqCre+ mice (termed Pkm2fl/fl Adipoq deficient) in our subsequent studies.