CD8A and graft versus host disease: In this study, we examined the role of CD8+ T cells in GVHD and the composition of human immune cells in these mice by inducing the lack of CD8+ T cells in mice with transplanted PBMCs (CD8TΔhPBMC mice) and observed their phenotypes (Figure 1A and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.191700DS1).