On one hand, H2S has been shown to promote proliferation, inhibit apoptosis, and enhance angiogenesis and migration of PLC/PRF/5 hepatoma cells via activation of the NF-κB or signal transducer and activator of transcription 3 (STAT3)-cyclooxygenase−2 (COX−2) signalling pathways.162. This evidence concerns the gene STAT3 and hepatocellular carcinoma.