Specifically, the index SNV rs429358 at 19q13.32 (PLACO p = 7.99 × 10−57) in APOE, a gene associated with various physiological processes including cholesterol metabolism and Alzheimer's disease risk, was significantly associated with AD (original GWAS p = 0, recalculated p < 2.2 × 10−16) but not with DVD GWAS. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.