MTOR and Alzheimer disease: MTOR (mechanistic target of rapamycin kinase) is a component of the MTORC1 and MTORC2 complexes that negatively regulate autophagy by phosphorylation of ULK1 at its S757 inhibitory residue; MTOR is hyperactive in AD which inhibits autophagic clearance of pathologically associated protein aggregates [500].