Patients with hereditary spastic paraplegia type 49 (SPG49), caused by mutations in TECPR2 (tectonin beta-propeller repeat containing 2), present with a thin corpus callosum, cerebral and cerebellar atrophy, and moderate to severe intellectual disability, with TECPR2 playing a role in autophagy by maintaining endoplasmic exit sites for autophagosome formation [475]. This evidence concerns the gene TECPR2 and hereditary spastic paraplegia 49.