Mutations in KIF1A (resulting in KIF1-associated neurological disorder/KAND) [291], KIF1B (resulting in Charcot-Marie-Tooth disease) [293], KIF5A (resulting in ALS) [294], and KIF21B (causing neurodevelopmental disorders) [295] result in various neurological disorders where intracellular transport defects are evident. Here, KIF5A is linked to amyotrophic lateral sclerosis.