Systematic evaluation of PD-linked coding variants in PINK1 and PRKN reveal disruption of normal protein expression, PINK1 autophosphorylation, PRKN translocation to mitochondria, PRKN phosphorylation by PINK1, the generation of p-S65-Ub, and mitophagic flux [361–364]. The gene discussed is PRKN; the disease is Parkinson disease.