While tau aggregates, called tangles, are prominently associated with AD, mutations in MAPT are primarily linked to FTD (pathologically, frontotemporal lobar degeneration with MAPT/tau pathology, or FTLD-MAPT/tau), which includes progressive supranuclear palsy, corticobasal degeneration, and Pick disease [403]. Here, MAPT is linked to Classical progressive supranuclear palsy.