This connection is further supported by the understanding that MDK, as a heparin‐binding growth factor, plays a role in neuro‐immune crosstalk under pathological conditions, as indicated by its increased levels in the periphery and central nervous system (CNS) during various pathological states.[42] This suggests that MDK is not only a mediator of disease processes within specific compartments but also a facilitator of neuro‐immune cell‐to‐cell communication, which is crucial in the context of AKI‐related cognitive impairment. Here, MDK is linked to acute kidney injury.