Furthermore, our observation of elevated serum MDK levels in mice subjected to post‐ischemic renal injury is corroborated by Şalaru et al., who reported increased MDK levels in advanced AKI patients, indicating its potential as a biomarker for renal injury.[41] This underscores the relevance of MDK in AKI to CKD pathophysiology and its association with disease severity. This evidence concerns the gene MDK and acute kidney injury.