PRDM1 and non-small cell lung carcinoma: Importantly, studies using NSCLC patient-derived organoids (PDOs) and humanized PDO-NSG chimeras confirmed that blocking acetyl-CoA production, exosome secretion from CSCs, and key enzymes involved in Blimp-1 acetylation and ubiquitination effectively restores CD103<sup>+</sup> T cell differentiation.