SIRT3 and familial dilated cardiomyopathy: [45] found that LncDACH1 directly binds to SIRT3 and promotes its degradation through ubiquitination, thereby promoting mitochondrial oxidative damage and apoptosis in the hearts of DCM mice, whereas SIRT3 silencing abrogated the protective effect of lncDACH1 deficiency on cardiomyocytes.