While these devices have revolutionized the care of children with T1D, resulting in improved overall glycemic outcomes, reduced risk of hypoglycemia, and decreased disease burden,25–27 prior studies have suggested that their use may in fact be associated with the aforementioned maladaptive prandial practices28–30 and delivery of higher insulin doses,27 at least partially in response to post-prandial glycemic excursions. This evidence concerns the gene INS and Hypoglycemia.