LONP1 and lipoprotein glomerulopathy: Building on our previous finding that podocyte-specific LONP1 knockout induces podocyte injury and glomerulopathy [23], we propose that MnTBAP protects against podocyte damage through a dual mechanism: direct antioxidant defense in LONP1-reduced podocytes, and indirect protection of endothelial function to maintain a healthy glomerular environment.