Additional scRNAseq analysis highlighted a main expression of IL-18 and IL-18BP in hepatic macrophages, while IL-18 receptor expression, indirectly reflecting IL-18 cellular targets, is predominant in NK cells, ILC1s, and different T-cell subpopulations, all previously implicated in MASH.18, 19. This evidence concerns the gene IL18 and metabolic dysfunction-associated steatohepatitis.