Notably the increased oxidative-phosphorylation-dependent ATP production in the MITF KO requires TFEB and TFE3 and is consistent with MITFLow slow-cycling melanoma cells exhibiting elevated oxidative phosphorylation.100,101 Taken together, our data implicate TFEB and TFE3 as playing a key role in the metabolic switch associated with loss of MITF. The gene discussed is TFEB; the disease is melanoma.