The results are consistent with evidence highlighting MITF, and by implication, TFE3 and/or TFEB, in control of the anti-tumor immune response.81,102,103 Given the importance of immune infiltration in the response to immune checkpoint blockade, our results provide a clear path to future studies directed at dissecting the molecular mechanisms controlling the tumor immune microenvironment. The gene discussed is TFEB; the disease is neoplasm.