MITF and melanoma: Importantly, chromatin immunoprecipitation sequencing (ChIP-seq)64 revealed MITF binding to the promoters of RRAGD and isoform 2 of FNIP2 (Figure 1E) and FNIP2, and RRAGD expression was lower in the MITFLow WM793 and IGR39 melanoma cell lines compared to MITFHigh IGR37 and 501mel cells (Figure 1F).