Interestingly, AXL, encoding a key receptor tyrosine kinase linked to therapy resistance,29,30 is expressed in MITFLow melanoma cells and can be activated by unsaturated fatty acids.85AXL is not bound by any MITF family member but is upregulated in the MITF/TFEB DKO (Figure 6H) but not in the TKO. This evidence concerns the gene TFEB and melanoma.