However, while MITF expression is reduced in invasive cells23 that have elevated tumor-initiating ability25,28 and exhibit non-genetic therapy resistance,29–32 for invasive cells to generate a new metastasis, MITF should be re-expressed to allow proliferation.15,33 Despite these insights, our understanding of the molecular adaptations occurring as cells are subject to potentially lethal stresses during disease progression remains incomplete. Here, MITF is linked to neoplasm.