A proportion of X‐linked genes escape X‐chromosome inactivation, which leads to elevated expression levels of certain immune‐related genes in females, such as Toll‐like receptor 7 (TLR7) and the histone demethylase KDM6A. 113 This genetic background may contribute to differences in anti‐tumour immune responses between the sexes. Here, KDM6A is linked to neoplasm.