Analysis of immune cell compositions across various cancer stages and non‐malignant tissues revealed two macrophage subsets: a pro‐angiogenic subset linked to poor survival via the NF‐κB signalling pathway and an interferon‐primed subset associated with improved survival, capable of recruiting T cells through CXCL9/10/11–CXCR3 interactions. Here, NFKB1 is linked to cancer.