Crucially, comprehensive profiling uncovers co‐occurring drivers (e.g., synchronous EML4‐ALK and TPM3‐ROS1 in bilateral lung adenocarcinomas) or histologic mimics (e.g., TPM3‐ALK+ cutaneous epithelioid vascular tumors masquerading as melanocytic lesions). The gene discussed is ALK; the disease is lung adenocarcinoma.