ATG4B and acute lymphoblastic leukemia: The Venn diagram shows that 24 transcripts were upregulated in ATG4B-silenced cells while downregulated in T-ALL samples in comparison to NBM cells; conversely, seven transcripts were downregulated in ATG4B-silenced cells while upregulated in T-ALL samples (Fig. 3B), suggesting that these differentially expressed transcripts may play a role in human T-ALL pathology.