To explore the role of SESN3 in T-ALL, SESN3 expression was firstly measure by RT‒qPCR, and the results showed that SESN3 expression was significantly lower in T-ALL patient samples (n = 12) than control cells (n = 8) (p < 0.05, Fig. 5A), which was supported by data from GSE26713 (p < 0.01, Fig. 5B) and GSE13159 (p < 0.001, Fig. 5C). The gene discussed is SESN3; the disease is acute lymphoblastic leukemia.