Several studies have demonstrated that persistent high fever, elevated lactate dehydrogenase (LDH) and Interleukin-6 (IL-6) levels, decreased platelet count (PLT), extrapulmonary complications, pleural effusion, and atelectasis serve as significant predictive indicators for PB formation in patients with RMPP [9, 12]. The gene discussed is IL6; the disease is Pleural effusion.